Medicated hydroxyapatite/collagen hybrid scaffolds for bone regeneration and local antimicrobial therapy to prevent bone infections

Manuela Mulazzi, Elisabetta Campodoni, Giada Bassi, Monica Montesi, Silvia Panseri, Francesca Bonvicini, Giovanna Angela Gentilomi, Anna Tampieri, Monica Sandri

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Microbial infections occurring during bone surgical treatment, the cause of osteomyelitis and implant failures, are still an open challenge in orthopedics. Conventional therapies are often ineffective and associated with serious side effects due to the amount of drugs administered by systemic routes. In this study, a medicated osteoinductive and bioresorbable bone graft was designed and investigated for its ability to control antibiotic drug release in situ. This represents an ideal solution for the eradication or prevention of infection, while simultaneously repairing bone defects. Vancomycin hydrochloride and gentamicin sulfate, here considered for testing, were loaded into a previously developed and largely investigated hybrid bone-mimetic scaffold made of collagen fibers biomineralized with magnesium doped-hydroxyapatite (MgHA/Coll), which in the last ten years has widely demonstrated its effective potential in bone tissue regeneration. Here, we have explored whether it can be used as a controlled local delivery system for antibiotic drugs. An easy loading method was selected in order to be reproducible, quickly, in the operating room. The maintenance of the antibacterial efficiency of the released drugs and the biosafety of medicated scaffolds were assessed with microbiological and in vitro tests, which demonstrated that the MgHA/Coll scaffolds were safe and effective as a local delivery system for an extended duration therapy—promising results for the prevention of bone defect-related infections in orthopedic surgeries.

Original languageEnglish (US)
Article number1090
JournalPharmaceutics
Volume13
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Biomimetic materials
  • Bone regeneration
  • Gentamicin sulfate
  • Local therapy
  • Microbial bone infection
  • Vancomycin hydrochloride

ASJC Scopus subject areas

  • Pharmaceutical Science

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