Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Neuroblastic tumors are a group of tumors of the sympathetic ganglia and adrenal medulla that derive from primordial neural crest cells. These tumors include neuroblastoma, intermixed ganglioneuroblastoma, nodular ganglioneuroblastoma, and ganglioneuroma. Neuroblastomas are the most common extracranial solid tumor arising in childhood and may occur in different anatomic sites. Neuroblastic tumors are common mesenchymal tumors of the mediastinum. Herein, we describe advances in our understanding of neuroblastic tumor biology. Pathologists should be aware of diagnostic challenges associated with these tumors to ensure correct histologic diagnosis and appropriate clinical management. We describe updated mediastinal neuroblastic tumor pathology, focusing on morphological, immunohistochemical, and molecular features and differential diagnoses.

Original languageEnglish (US)
Pages (from-to)120-130
Number of pages11
JournalSeminars in Diagnostic Pathology
Issue number2
StatePublished - Mar 2022


  • Ganglioneuroblastoma
  • Ganglioneuroma
  • Mediastinum
  • Neuroblastic tumor
  • Neuroblastoma
  • Humans
  • Mediastinal Neoplasms/diagnosis
  • Neuroblastoma/diagnosis
  • Ganglioneuroma/diagnosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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