Medial Frontal Hyperactivity in Reality Distortion

Stephan F. Taylor, Robert C. Welsh, Ashley C. Chen, Alan J. Velander, Israel Liberzon

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background: Schizophrenia/schizoaffective disorder involves reality distortion (RD), which impairs the ability to process socioemotional information. Because this psychological capacity maps to the medial prefrontal cortex (MPFC) and schizophrenia involves abnormal MPFC function, we tested the hypothesis that treated schizophrenic/schizoaffective patients with persistent RD (RD+) would exhibit greater MPFC dysfunction than patients without significant RD (RD-). The amygdala interacts with MPFC, also carries out socioemotional processing, and has been implicated in schizophrenia; thus, we also tested the hypothesis that patients would exhibit aberrant amygdala activity. Methods: Eleven RD+ patients, 12 RD- patients, and 15 healthy control subjects (HC) viewed emotionally salient pictures with neutral, aversive, and positive content during the acquisition of blood oxygenation level-dependent (BOLD) sensitive functional magnetic resonance imaging. Results: All groups had similar behavioral responses to the pictures. The RD+ subjects had greater BOLD responses (compared with the RD- and HC groups) to the aversive pictures in the anterior MPFC. Both patient groups showed reduced activation in MPFC and the left amygdala (compared with HC) for neutral pictures (compared with blank condition), although this effect could be explained by medication. Conclusions: Reality distortion is associated with hyperactivity of the MPFC in schizophrenic/schizoaffective patients whose symptoms persist in spite of antipsychotic treatment.

Original languageEnglish (US)
Pages (from-to)1171-1178
Number of pages8
JournalBiological Psychiatry
Issue number10
StatePublished - May 15 2007


  • Emotion
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry


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