Mechanisms regulating body distribution of nanospheres conditioned with pluronic and tetronic block co-polymers

S. M. Moghimi

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Block co-polymers of poloxamer and poloxamine types have been used to alter the surface characteristics of model nanosphere beads of different sizes. Such modifications, depending on the molecular nature of the block co-polymers, can affect opsonization processes and the overall body distribution of beads following parenteral administration. Certain block co-polymers were able to make nanospheres 'phagocyte resistant' and to keep them away from Kupffer cells in the liver and, concomitantly, prolong their circulation time in the blood. In other cases, selective bone marrow, spleen and lymph node delivery of beads have been demonstrated. Moreover, a number of poloxamer and poloxamine block co-polymers can enhance the body's defence system both at humoral and cellular levels. The prototype beads described may have implications in radiodiagnostic imaging and organ-specific drug delivery.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume16
Issue number2-3
DOIs
StatePublished - Sep 1995

Keywords

  • Drug carrier systems
  • Kupffer cells
  • Liver
  • Macrophage
  • Nanosphere
  • Opsonins
  • Poloxamer
  • Poloxamine
  • Reticuloendothelial system
  • Spleen

ASJC Scopus subject areas

  • Pharmaceutical Science

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