Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ1 transactivation domain

Iain J. McEwan; Karin Dahlman-Wright; Tova Amlöf; Jacqueline Ford; Anthony P.H. Wright; Jan Åke Gustafsson

doi:10.1016/0027-5107(95)00126-3

Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ₁ transactivation domain

Iain J. McEwan, Karin Dahlman-Wright, Tova Amlöf, Jacqueline Ford, Anthony P.H. Wright, Jan Åke Gustafsson

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Nuclear receptors are important signalling molecules that directly mediate the effects of hormones, vitamins and xenobiotic compounds at the level of gene expression. Several members of this superfamily of proteins have been implicated in receptor-dependent carcinogenesis. In this review, we summarise how these receptors can function as transcription factors with particular emphasis on the mechanism of transcription activation by the human glucocorticoid receptor τ₁ transactivation domain.

Original language	English (US)
Pages (from-to)	15-22
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	333
Issue number	1-2
DOIs	https://doi.org/10.1016/0027-5107(95)00126-3
State	Published - Dec 1995

Keywords

Glucocorticoid receptor τ
Nuclear receptor
Transcription activation
Transcription factor

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Molecular Biology
Genetics

Access to Document

10.1016/0027-5107(95)00126-3

Cite this

McEwan, I. J., Dahlman-Wright, K., Amlöf, T., Ford, J., Wright, A. P. H., & Gustafsson, J. Å. (1995). Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ₁ transactivation domain. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 333(1-2), 15-22. https://doi.org/10.1016/0027-5107(95)00126-3

Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ₁ transactivation domain. / McEwan, Iain J.; Dahlman-Wright, Karin; Amlöf, Tova et al.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 333, No. 1-2, 12.1995, p. 15-22.

Research output: Contribution to journal › Article › peer-review

McEwan, IJ, Dahlman-Wright, K, Amlöf, T, Ford, J, Wright, APH & Gustafsson, JÅ 1995, 'Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ₁ transactivation domain', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 333, no. 1-2, pp. 15-22. https://doi.org/10.1016/0027-5107(95)00126-3

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