Mechanisms of transcription activation by nuclear receptors: studies on the human glucocorticoid receptor τ1 transactivation domain

Iain J. McEwan, Karin Dahlman-Wright, Tova Amlöf, Jacqueline Ford, Anthony P.H. Wright, Jan Åke Gustafsson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Nuclear receptors are important signalling molecules that directly mediate the effects of hormones, vitamins and xenobiotic compounds at the level of gene expression. Several members of this superfamily of proteins have been implicated in receptor-dependent carcinogenesis. In this review, we summarise how these receptors can function as transcription factors with particular emphasis on the mechanism of transcription activation by the human glucocorticoid receptor τ1 transactivation domain.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume333
Issue number1-2
DOIs
StatePublished - Dec 1995

Keywords

  • Glucocorticoid receptor τ
  • Nuclear receptor
  • Transcription activation
  • Transcription factor

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Molecular Biology
  • Genetics

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