Abstract
The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-115 |
| Number of pages | 13 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1995 |
Keywords
- Filtration
- Macrophage
- Phagocytosis
- Spleen macrophage
- Splenic blood flow pathway
ASJC Scopus subject areas
- Pharmaceutical Science
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