Mechanisms of splenic clearance of blood cells and particles: towards development of new splenotropic agents

S. M. Moghimi

    Research output: Contribution to journalReview articlepeer-review

    130 Scopus citations

    Abstract

    The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.

    Original languageEnglish (US)
    Pages (from-to)103-115
    Number of pages13
    JournalAdvanced Drug Delivery Reviews
    Volume17
    Issue number1
    DOIs
    StatePublished - Oct 1995

    Keywords

    • Filtration
    • Macrophage
    • Phagocytosis
    • Spleen macrophage
    • Splenic blood flow pathway

    ASJC Scopus subject areas

    • Pharmaceutical Science

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