TY - JOUR
T1 - Mechanisms of splenic clearance of blood cells and particles
T2 - towards development of new splenotropic agents
AU - Moghimi, S. M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1995/10
Y1 - 1995/10
N2 - The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.
AB - The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.
KW - Filtration
KW - Macrophage
KW - Phagocytosis
KW - Spleen macrophage
KW - Splenic blood flow pathway
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U2 - 10.1016/0169-409X(95)00043-7
DO - 10.1016/0169-409X(95)00043-7
M3 - Review article
AN - SCOPUS:0029379535
SN - 0169-409X
VL - 17
SP - 103
EP - 115
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 1
ER -