Mechanisms of splenic clearance of blood cells and particles: towards development of new splenotropic agents

S. M. Moghimi

Research output: Contribution to journalReview article

112 Scopus citations

Abstract

The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.

Original languageEnglish (US)
Pages (from-to)103-115
Number of pages13
JournalAdvanced Drug Delivery Reviews
Volume17
Issue number1
DOIs
StatePublished - Oct 1995

Keywords

  • Filtration
  • Macrophage
  • Phagocytosis
  • Spleen macrophage
  • Splenic blood flow pathway

ASJC Scopus subject areas

  • Pharmaceutical Science

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