Mechanisms of PARP-Inhibitor-Resistance in BRCA-Mutated Breast Cancer and New Therapeutic Approaches

Keyphrases

• Breast Cancer Treatment 100%
• New Therapeutic Approaches 100%
• PARP Inhibitor (PARPi) 100%
• Inhibitor Resistance 100%
• BRCA-associated Breast Cancer 100%
• Molecular Mechanism 22%
• BRCA1, BRCA2 22%
• Breast Cancer 11%
• DNA Damage 11%
• Resistance Mechanisms 11%
• Ovarian Cancer 11%
• Patient with Tumor 11%
• Potential Therapeutic Strategies 11%
• Patient Experience 11%
• Acquired Resistance 11%
• Innate Resistance 11%
• Strategies to Overcome 11%
• Intrinsic Resistance 11%
• Long-term Response 11%
• Homologous Recombination Deficiency 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 100%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 100%
• Lethality 12%
• Intrinsic Resistance 12%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 12%

Immunology and Microbiology

• Homologous Recombination 100%
• DNA Damage 100%