Mechanisms of disease: is mitochondrial function altered in heart failure?

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Issue number1
StatePublished - 2013

ASJC Scopus subject areas

  • Medicine(all)


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