Mechanisms and pathways of innate immune activation and regulation in health and cancer

Jun Cui, Yongjun Chen, Helen Y. Wang, Rong Fu Wang

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in turn, instructs adaptive immune response development. Despite the diverse functions employed by innate immune signaling to respond to a variety of different pathogens, the innate immune response must be tightly regulated. Otherwise, aberrant, uncontrolled immune responses will lead to harmful, or even fatal, consequences. Therefore, it is essential to better discern innate immune signaling and many regulators, controlling various signaling pathways, have been identified. In this review, we focus on the recent advances in our understanding of the activation and regulation of innate immune signaling in the host response to pathogens and cancer.

Original languageEnglish (US)
Pages (from-to)3270-3285
Number of pages16
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cancer
  • Inflammation
  • Innate immunity
  • PRRs
  • Type I interferon

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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