Mechanism of release of gastric luminal somatostatin-like immunoreactivity in response to pentagastrin and sham feeding in man

A. Ozden, H. Degertekin, A. O. Yeginsu, A. Ertan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We studied in five healthy volunteers whether the cholinergic pathway regulated the secretion of gastric intraluminal somatostatin-like immunoreactivity (SLI) in response to stimuli of pentagastrin infusion (0.9 μg/kg/h, intravenously) and sham feeding. We measured gastric secretory volume, hydrogen ion output, and SLI at base line, during pentagastrin infusion, after sham feeding, and after applications of atropine (0.0, 0.7, 7.0 μg/kg, intramuscularly) given before pentagastrin and sham feeding. The stimuli were given randomly, at separate times on different days. After each stimulus, eight 15-min gastric juice collections were made; samples were adjusted to pH 7, pepstatin-A and aprotinin were added, and samples were extracted with acetone to determine SLI by radioimmunoassay. Pentagastrin and sham feeding significantly increased gastric luminal SLI secretion, which appeared to correlate with the increases in volume and acid output. Atropine at 7 μg/kg significantly suppressed gastric volume, acid, and SLI outputs stimulated by sham feeding; however, responses to pentagastrin stimulation remained unchanged. To conclude, the cholinergic mechanism regulates gastric intraluminal SLI response to sham feeding but not to pentagastrin infusion.

Original languageEnglish (US)
Pages (from-to)1257-1262
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume22
Issue number10
DOIs
StatePublished - 1987

Keywords

  • Gastric
  • Intraluminal
  • Pentagastrin
  • Sham feeding
  • Somatostatin-like immunoreactivity

ASJC Scopus subject areas

  • Gastroenterology

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