Mechanism of oestrogen signalling with particular reference to the role of ERβ in the central nervous system

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

The discovery of a second oestrogen receptor (ER), ERβ, has drastically changed our view of oestrogen action. Since the two ERs, ERα and ERβ, have somewhat different tissue and cellular distribution as well as ligand binding specificity the possibility exists that they have different biological roles. Indeed, several observations seem to indicate that they may even have opposite effects so that ERβ diminishes the activity of ERα. The CNS contains both ERα and ERβ and it is conceivable that they may have specific and individual roles in oestrogen signalling in the brain.

Original languageEnglish
Title of host publicationNovartis Foundation Symposium
Pages7-19
Number of pages13
Volume230
StatePublished - Dec 1 2000

Publication series

NameNovartis Foundation Symposium
Volume230

ASJC Scopus subject areas

  • Medicine(all)

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