TY - JOUR
T1 - Mechanism of gene expression by the glucocorticoid receptor
T2 - Role of protein-protein interactions
AU - McEwan, Iain J.
AU - Wright, Anthony P.H.
AU - Gustafsson, Jan Åke
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1997/2
Y1 - 1997/2
N2 - The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.
AB - The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.
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U2 - 10.1002/bies.950190210
DO - 10.1002/bies.950190210
M3 - Review article
C2 - 9046245
AN - SCOPUS:0031081426
SN - 0265-9247
VL - 19
SP - 153
EP - 160
JO - BioEssays
JF - BioEssays
IS - 2
ER -