Mechanism of gene expression by the glucocorticoid receptor: Role of protein-protein interactions

Iain J. McEwan, Anthony P.H. Wright, Jan Åke Gustafsson

    Research output: Contribution to journalReview articlepeer-review

    161 Scopus citations

    Abstract

    The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.

    Original languageEnglish (US)
    Pages (from-to)153-160
    Number of pages8
    JournalBioEssays
    Volume19
    Issue number2
    DOIs
    StatePublished - Feb 1997

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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