Mechanism of gene expression by the glucocorticoid receptor: Role of protein-protein interactions

Iain J. McEwan, Anthony P.H. Wright, Jan-Ake Gustafsson

Research output: Contribution to journalReview article

155 Scopus citations

Abstract

The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalBioEssays
Volume19
Issue number2
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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