Mechanism of action of α-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells

Keyphrases

• Mechanism of Action 100%
• α-Naphthoflavone 100%
• Human Breast Cancer Cells 100%
• MCF-7 100%
• Aryl Hydrocarbon Receptor Antagonist 100%
• 2,3,7,8-tetrachlorodibenzo-p-dioxin 69%
• Antiestrogen 53%
• MCF-7 Cells 46%
• 17-estradiol 23%
• Nuclear Extract 23%
• Dioxins 23%
• Aryl Hydrocarbon Receptor 23%
• Responsive Element 23%
• Gene Expression 15%
• Co-treatment 15%
• Receptor Complex 15%
• CYP1A1 Gene 15%
• Estrogen Receptor 7%
• Transcriptionally Active 7%
• Cell Proliferation 7%
• Estrogen 7%
• Induced Proliferation 7%
• Incubation 7%
• Concentration-dependent 7%
• Antiproliferative Activity 7%
• Methyl 7%
• Agonist Activity 7%
• Nuclear Estrogen Receptor 7%
• Gel Shift Assay 7%
• Induced Response 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 100%
• Aromatic Hydrocarbon Receptor 100%
• 2,3,7,8-Tetrachlorodibenzodioxin 100%
• Receptor Antagonist 100%
• 1,3,8 Trichloro 6 Methyldibenzofuran 44%
• Diethylstilbestrol 33%
• Antiestrogen 33%
• Dioxins and Dioxin-Like Compounds 33%
• Estrogen Receptor 22%
• Tamoxifen 22%
• Cytochrome P450 1A1 22%
• Receptor Agonist 11%
• Electrophoretic Mobility Shift Assay 11%
• Nuclear Estrogen 11%