Mechanical spectral signatures of malignant disease? A small-sample, comparative study of continuum vs. nano-biomechanical data analyses

Jun Liu, Mauro Ferrari

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Thin sections from human breast biopsies were employed to perform a differential analysis of the ultrasound spectral responses from invasive ductal carcinoma and normal tissue. A non-destructive testing methodology was employed, yielding the reflection coefficients as function of frequency in the clinical ultrasound range. The spectral responses were simulated both in the context of continuum and nano-biomechanics, with the objective of quantifying the physical properties that determine the differences in the spectral signature of normal vs. malignant tissue. The properties that were employed for the theoretical reconstruction of the spectra were: the density, the continuum and the nanomechanical elastic constants, and the nanomechanical theory internodal distance. The latter is a measure of the depth-of-penetration of mechanical actions between contiguous tissue elements. Together with vectorial descriptors of the tissue spatial arrangement, the internodal distance variable affords the quantitative incorporation of tissue architectural data in the theoretical model. In this paper, the validity of the nanomechanical approach to tissue characterization is discussed, and its potential extensions to biomolecular marker-based cancer diagnostics and therapeutics are considered.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalDisease Markers
Volume18
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Biomechanics
  • Cancer markers
  • Invasive ductal carcinoma
  • Nanomechanics
  • Physical properties of tissue
  • Tissue microstructure
  • Ultrasound

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry

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