Mechanical resonant immunospecific biological detector

B. Ilic, D. Czaplewski, H. G. Craighead, P. Neuzil, C. Campagnolo, C. Batt

Research output: Contribution to journalArticle

382 Scopus citations

Abstract

We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Measured resonant frequency shift as a function of the additional cell loading was observed and correlated to the mass of the specifically bound Escherichia coli OI57:H7 cells. Deposition and subsequent detection of E. coli cells was achieved under ambient conditions.

Original languageEnglish (US)
Pages (from-to)450-452
Number of pages3
JournalApplied Physics Letters
Volume77
Issue number3
DOIs
StatePublished - Jul 17 2000

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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