Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes

Navin K. Kapur; Manreet K. Kanwar; Rayan Yousefzai; Arvind Bhimiraj; Harrison Farber; Michele L. Esposito; Michael S. Kiernan; Kevin J. John; Daniel Burkhoff

doi:10.1097/MAT.0000000000002240

Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes

Navin K. Kapur, Manreet K. Kanwar, Rayan Yousefzai, Arvind Bhimiraj, Harrison Farber, Michele L. Esposito, Michael S. Kiernan, Kevin J. John, Daniel Burkhoff

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Decongestion is a cornerstone therapeutic goal for those presenting with decompensated heart failure. Current approaches to clinical decongestion include reducing cardiac preload, which is typically limited to diuretics and hemofiltration. Several new technologies designed to mechanically reduce cardiac preload are in development. In this review, we discuss the pathophysiology of decompensated heart failure; the central role of targeting cardiac preload; emerging mechanical preload reduction technologies; and potential application of these devices.

Original language	English (US)
Pages (from-to)	821-831
Number of pages	11
Journal	ASAIO Journal
Volume	70
Issue number	10
DOIs	https://doi.org/10.1097/MAT.0000000000002240
State	Published - Oct 1 2024

Keywords

heart failure
mechanical circulatory support
preload
Hemofiltration/methods
Diuretics/therapeutic use
Humans
Treatment Outcome
Heart Failure/therapy

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1097/MAT.0000000000002240

Cite this

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title = "Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes",

abstract = "Decongestion is a cornerstone therapeutic goal for those presenting with decompensated heart failure. Current approaches to clinical decongestion include reducing cardiac preload, which is typically limited to diuretics and hemofiltration. Several new technologies designed to mechanically reduce cardiac preload are in development. In this review, we discuss the pathophysiology of decompensated heart failure; the central role of targeting cardiac preload; emerging mechanical preload reduction technologies; and potential application of these devices.",

keywords = "heart failure, mechanical circulatory support, preload, Hemofiltration/methods, Diuretics/therapeutic use, Humans, Treatment Outcome, Heart Failure/therapy",

author = "Kapur, {Navin K.} and Kanwar, {Manreet K.} and Rayan Yousefzai and Arvind Bhimiraj and Harrison Farber and Esposito, {Michele L.} and Kiernan, {Michael S.} and John, {Kevin J.} and Daniel Burkhoff",

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T2 - Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes

AU - Kapur, Navin K.

AU - Kanwar, Manreet K.

AU - Yousefzai, Rayan

AU - Bhimiraj, Arvind

AU - Farber, Harrison

AU - Esposito, Michele L.

AU - Kiernan, Michael S.

AU - John, Kevin J.

AU - Burkhoff, Daniel

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Decongestion is a cornerstone therapeutic goal for those presenting with decompensated heart failure. Current approaches to clinical decongestion include reducing cardiac preload, which is typically limited to diuretics and hemofiltration. Several new technologies designed to mechanically reduce cardiac preload are in development. In this review, we discuss the pathophysiology of decompensated heart failure; the central role of targeting cardiac preload; emerging mechanical preload reduction technologies; and potential application of these devices.

AB - Decongestion is a cornerstone therapeutic goal for those presenting with decompensated heart failure. Current approaches to clinical decongestion include reducing cardiac preload, which is typically limited to diuretics and hemofiltration. Several new technologies designed to mechanically reduce cardiac preload are in development. In this review, we discuss the pathophysiology of decompensated heart failure; the central role of targeting cardiac preload; emerging mechanical preload reduction technologies; and potential application of these devices.

KW - heart failure

KW - mechanical circulatory support

KW - preload

KW - Hemofiltration/methods

KW - Diuretics/therapeutic use

KW - Humans

KW - Treatment Outcome

KW - Heart Failure/therapy

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Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes

Abstract

Keywords

ASJC Scopus subject areas

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