mecA-blaZ corepressors in clinical Staphylococcus aureus isolates

Adriana E. Rosato, Barry N. Kreiswirth, William A. Craig, William Eisner, Michael W. Climo, Gordon L. Archer

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

Original languageEnglish (US)
Pages (from-to)1460-1463
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number4
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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