Measuring coronary artery calcification: Is serum vitamin D relevant?

Rehan Malik; Ehimen C. Aneni; Lara Roberson; Oluseye Ogunmoroti; Shozab S. Ali; Sameer Shaharyar; Adnan Younus; Omar Jamal; Muhammad A. Aziz; Seth S. Martin; Michael J. Blaha; Theodore Feldman; Arthur S. Agatston; Emir Veledar; Khurram Nasir

doi:10.1016/j.atherosclerosis.2014.10.087

Measuring coronary artery calcification: Is serum vitamin D relevant?

Rehan Malik, Ehimen C. Aneni, Lara Roberson, Oluseye Ogunmoroti, Shozab S. Ali, Sameer Shaharyar, Adnan Younus, Omar Jamal, Muhammad A. Aziz, Seth S. Martin, Michael J. Blaha, Theodore Feldman, Arthur S. Agatston, Emir Veledar, Khurram Nasir

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

Original language	English (US)
Pages (from-to)	734-738
Number of pages	5
Journal	Atherosclerosis
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2014.10.087
State	Published - Dec 1 2014

Keywords

Atherosclerosis
Coronary artery calcification
Serum vitamin D

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2014.10.087

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@article{41717dfb44ae4d52b291f684056515a1,

title = "Measuring coronary artery calcification: Is serum vitamin D relevant?",

abstract = "Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.",

keywords = "Atherosclerosis, Coronary artery calcification, Serum vitamin D",

author = "Rehan Malik and Aneni, {Ehimen C.} and Lara Roberson and Oluseye Ogunmoroti and Ali, {Shozab S.} and Sameer Shaharyar and Adnan Younus and Omar Jamal and Aziz, {Muhammad A.} and Martin, {Seth S.} and Blaha, {Michael J.} and Theodore Feldman and Agatston, {Arthur S.} and Emir Veledar and Khurram Nasir",

note = "Publisher Copyright: {\textcopyright} 2014.",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.atherosclerosis.2014.10.087",

language = "English (US)",

volume = "237",

pages = "734--738",

journal = "Atherosclerosis",

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TY - JOUR

T1 - Measuring coronary artery calcification

T2 - Is serum vitamin D relevant?

AU - Malik, Rehan

AU - Aneni, Ehimen C.

AU - Roberson, Lara

AU - Ogunmoroti, Oluseye

AU - Ali, Shozab S.

AU - Shaharyar, Sameer

AU - Younus, Adnan

AU - Jamal, Omar

AU - Aziz, Muhammad A.

AU - Martin, Seth S.

AU - Blaha, Michael J.

AU - Feldman, Theodore

AU - Agatston, Arthur S.

AU - Veledar, Emir

AU - Nasir, Khurram

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

AB - Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

KW - Atherosclerosis

KW - Coronary artery calcification

KW - Serum vitamin D

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Measuring coronary artery calcification: Is serum vitamin D relevant?

Abstract

Keywords

ASJC Scopus subject areas

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