Measuring coronary artery calcification: Is serum vitamin D relevant?

Rehan Malik, Ehimen C. Aneni, Lara Roberson, Oluseye Ogunmoroti, Shozab S. Ali, Sameer Shaharyar, Adnan Younus, Omar Jamal, Muhammad A. Aziz, Seth S. Martin, Michael J. Blaha, Theodore Feldman, Arthur S. Agatston, Emir Veledar, Khurram Nasir

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
Issue number2
StatePublished - Dec 1 2014


  • Atherosclerosis
  • Coronary artery calcification
  • Serum vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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