Maximizing opportunities for kidney transplantation in older adults

Vidya A. Fleetwood, Yasar Caliskan, Fadee Abu Al Rub, David Axelrod, Krista L. Lentine

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewTo summarize the current state of evidence related to the outcomes of older adults who need and receive kidney transplants, and strategies to facilitate appropriate transplant access in this at-risk group.Recent findingsOlder adults are a rapidly growing subgroup of the kidney transplant waitlist. Compared to younger adults, older kidney transplant recipients have increased mortality after kidney transplant and lower death-censored graft survival. In determining suitability for transplantation in older patients, clinicians must balance procedural and immunosuppression-related risk with incremental survival when compared with dialysis. To appropriately increase access to transplantation in this population, clinicians and policy makers consider candidates' chronological age and frailty, as well as the quality of and waiting time for a donated allograft. Given risk of deterioration prior to transplant, candidates should be rapidly evaluated, listed, and transplanted using living donor and or less than ideal deceased donor organs when available.SummaryAccess to transplantation for older adults can be increased through targeted interventions to address frailty and reduce waiting times through optimized organ use. Focused study and educational interventions for patients and providers are needed to improve the outcomes of this vulnerable group.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Issue number2
StatePublished - Mar 1 2023


  • aging
  • disparities
  • frailty
  • organ use
  • transplant access

ASJC Scopus subject areas

  • Medicine(all)


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