Matrix Metalloproteinases in Critical Limb Ischemia

Mark J. Hobeika, Rachel S. Edlin, Bart E. Muhs, Mikel Sadek, Paul J. Gagne

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Critical limb ischemia (CLI) is most commonly the result of arterial occlusive disease, specifically atherosclerotic plaque formation and rupture within the infrainguinal arteries. The physiological response to CLI is partial limb reperfusion via the distinct processes of angiogenesis and arteriogenesis. Matrix metalloproteinases (MMPs) are extracellular matrix-remodeling enzymes that play an important role in both the occlusion and reperfusion processes associated with CLI. This article provides a review of the recent literature, summarizing the current understanding of the role of MMPs in both the arterial occlusion and limb reperfusion associated with CLI. Specifically, the functions of MMPs in atherosclerosis, angiogenesis, and arteriogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalJournal of Surgical Research
Issue number1
StatePublished - Sep 2008


  • angiogenesis
  • arteriogenesis
  • atherosclerosis
  • critical limb ischemia
  • matrix metalloproteinases

ASJC Scopus subject areas

  • Surgery


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