TY - JOUR
T1 - Maternal immunization with pneumococcal polysaccharide vaccine in the third trimester of gestation
AU - Munoz, Flor M.
AU - Englund, Janet A.
AU - Cheesman, Coni C.
AU - Maccato, Maurizio L.
AU - Pinell, Phillip M.
AU - Nahm, Moon H.
AU - Mason, Edward
AU - Kozinetz, Claudia A.
AU - Thompson, Rachel A.
AU - Glezen, W. Paul
N1 - Funding Information:
The authors gratefully acknowledge the women and infants who participated in this study; the staff at the obstetric practices of Drs. Maccato, Pinell and Thompson; the staff at the local hospitals where deliveries occurred; the pediatricians at Kelsey Seybold Clinic and other local private groups that collaborated with the infants’ care and follow-up; and the nurses, physician assistants, laboratory technicians, and administrative staff at the Baylor Influenza Research Center Unit, for their effort and invaluable participation in the successful completion of this study. Financial support: Contract nos. AI-65316 and AI-85334 awarded by the National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
PY - 2001/12/12
Y1 - 2001/12/12
N2 - In a randomized, double blinded study, 23-valent pneumococcal polysaccharide vaccine (PSV) or conjugate Haemophilus influenzae type b (HbOC) vaccine was administered to 60 healthy women in the third trimester of gestation. Total IgG, IgG1, and IgG2 antibodies to pneumococcal serotypes 6B, 14, 19F and 23F were measured by ELISA in mothers prior to immunization, at delivery and 7 months after delivery, and in infants at birth (cord blood), 2 and 7 months after delivery. IgA was evaluated in breast milk at 2 and 7 months, and opsonophagocytic activity in cord blood. PSV was safe and immunogenic in pregnant women. Transplacental transmission of vaccine-specific antibodies was efficient. Maternal immunization with PSV resulted in significantly higher concentrations of pneumococcal antibodies in infants at birth and at 2 months of age, and greater functional opsonophagocytic activity of passively acquired IgG antibody.
AB - In a randomized, double blinded study, 23-valent pneumococcal polysaccharide vaccine (PSV) or conjugate Haemophilus influenzae type b (HbOC) vaccine was administered to 60 healthy women in the third trimester of gestation. Total IgG, IgG1, and IgG2 antibodies to pneumococcal serotypes 6B, 14, 19F and 23F were measured by ELISA in mothers prior to immunization, at delivery and 7 months after delivery, and in infants at birth (cord blood), 2 and 7 months after delivery. IgA was evaluated in breast milk at 2 and 7 months, and opsonophagocytic activity in cord blood. PSV was safe and immunogenic in pregnant women. Transplacental transmission of vaccine-specific antibodies was efficient. Maternal immunization with PSV resulted in significantly higher concentrations of pneumococcal antibodies in infants at birth and at 2 months of age, and greater functional opsonophagocytic activity of passively acquired IgG antibody.
KW - Maternal immunization
KW - Opsonophagocytosis
KW - Pneumococcal vaccine
UR - https://www.scopus.com/pages/publications/0035852334
UR - https://www.scopus.com/inward/citedby.url?scp=0035852334&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(01)00397-8
DO - 10.1016/S0264-410X(01)00397-8
M3 - Article
C2 - 11738746
AN - SCOPUS:0035852334
SN - 0264-410X
VL - 20
SP - 826
EP - 837
JO - Vaccine
JF - Vaccine
IS - 5-6
ER -