TY - JOUR
T1 - Maternal estrogen receptor-β expression during mouse gestation
AU - Spong, C. Y.
AU - McCune, S. K.
AU - Sternberg, E. M.
AU - Gustafsson, J. A.
PY - 2000
Y1 - 2000
N2 - Problem: Although estrogen receptor (ER)-α has been well characterized, the recently identified novel ER-β has not. In some tissues, there is overlap of the ERs, which allows for rescue in cases of deficiency; in other tissues, the ERs appear to have opposite effects. The objective of this study was to evaluate the expression of ER-β during pregnancy. Method of study: Pregnant mouse uteri (embryonic days 6-14, 16, 18) were studied. ER-α and ER-β oligonucleotide probes were end-labeled and in situ hybridization histochemistry was performed. Results: ER-β was strongly expressed in maternal ovaries; there was no other evidence of strong expression during gestation. ER-α was expressed in the uterus throughout gestation, with decreasing intensity as gestation progressed, and in maternal ovarian tissue. Conclusions: Differential expression of the two ERs was apparent during pregnancy, with ER-α playing a dominant role. This may have implications for selective drug treatment targeting estrogen receptors.
AB - Problem: Although estrogen receptor (ER)-α has been well characterized, the recently identified novel ER-β has not. In some tissues, there is overlap of the ERs, which allows for rescue in cases of deficiency; in other tissues, the ERs appear to have opposite effects. The objective of this study was to evaluate the expression of ER-β during pregnancy. Method of study: Pregnant mouse uteri (embryonic days 6-14, 16, 18) were studied. ER-α and ER-β oligonucleotide probes were end-labeled and in situ hybridization histochemistry was performed. Results: ER-β was strongly expressed in maternal ovaries; there was no other evidence of strong expression during gestation. ER-α was expressed in the uterus throughout gestation, with decreasing intensity as gestation progressed, and in maternal ovarian tissue. Conclusions: Differential expression of the two ERs was apparent during pregnancy, with ER-α playing a dominant role. This may have implications for selective drug treatment targeting estrogen receptors.
KW - Estrogen receptor alpha
KW - Estrogen receptor beta
KW - Pregnancy
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U2 - 10.1111/j.8755-8920.2000.440410.x
DO - 10.1111/j.8755-8920.2000.440410.x
M3 - Article
C2 - 11076098
AN - SCOPUS:0033669098
SN - 8755-8920
VL - 44
SP - 249
EP - 252
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 4
ER -