Maternal estrogen receptor-β expression during mouse gestation

C. Y. Spong, S. K. McCune, E. M. Sternberg, J. A. Gustafsson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Problem: Although estrogen receptor (ER)-α has been well characterized, the recently identified novel ER-β has not. In some tissues, there is overlap of the ERs, which allows for rescue in cases of deficiency; in other tissues, the ERs appear to have opposite effects. The objective of this study was to evaluate the expression of ER-β during pregnancy. Method of study: Pregnant mouse uteri (embryonic days 6-14, 16, 18) were studied. ER-α and ER-β oligonucleotide probes were end-labeled and in situ hybridization histochemistry was performed. Results: ER-β was strongly expressed in maternal ovaries; there was no other evidence of strong expression during gestation. ER-α was expressed in the uterus throughout gestation, with decreasing intensity as gestation progressed, and in maternal ovarian tissue. Conclusions: Differential expression of the two ERs was apparent during pregnancy, with ER-α playing a dominant role. This may have implications for selective drug treatment targeting estrogen receptors.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Issue number4
StatePublished - 2000


  • Estrogen receptor alpha
  • Estrogen receptor beta
  • Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology


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