Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration

Anna Tampieri, Elizaveta Kon, Monica Sandri, Elisabetta Campodoni, Massimiliano Dapporto, Simone Sprio

Research output: Contribution to journalReview articlepeer-review


The degeneration of osteochondral tissue represents one of the major causes of disability in modern society and it is expected to fuel the demand for new solutions to repair and regenerate the damaged articular joints. In particular, osteoarthritis (OA) is the most common complication in articular diseases and a leading cause of chronic disability affecting a steady increasing number of people. The regeneration of osteochondral (OC) defects is one of the most challenging tasks in orthopedics since this anatomical region is composed of different tissues, characterized by antithetic features and functionalities, in tight connection to work together as a joint. The altered structural and mechanical joint environment impairs the natural tissue metabolism, thus making OC regeneration even more challenging. In this scenario, marine-derived ingredients elicit ever-increased interest for biomedical applications as a result of their outstanding mechanical and multiple biologic properties. The review highlights the possibility to exploit such unique features using a combination of bio-inspired synthesis process and 3D manufacturing technologies, relevant to generate compositionally and structurally graded hybrid constructs reproducing the smart architecture and biomechanical functions of natural OC regions.

Original languageEnglish (US)
Article number212
JournalMarine Drugs
Issue number4
StatePublished - Mar 28 2023


  • 3D printing
  • apatites
  • fucoidans
  • hybrid materials
  • marine-derived ingredients
  • mutable collagen
  • osteochondral scaffold
  • Humans
  • Cartilage, Articular
  • Tissue Scaffolds/chemistry
  • Osteoarthritis
  • Tissue Engineering

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmaceutical Science


Dive into the research topics of 'Marine-Inspired Approaches as a Smart Tool to Face Osteochondral Regeneration'. Together they form a unique fingerprint.

Cite this