Mapping the mouse genome: Current status and future prospects

William F. Dietrich, Neal G. Copeland, Debra J. Gilbert, Joyce C. Miller, Nancy A. Jenkins, Eric S. Lander

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

The mouse is the best model system for the study of mammalian genetics and physiology. Because of the feasibility and importance of studying genetic crosses, the mouse genetic map has received tremendous attention in recent years. It currently contains over 14,000 genetically mapped markers, including 700 mutant loci, 3500 genes, and 6500 simple sequence length polymorphisms (SSLPs). The mutant loci and genes allow insights and correlations concerning physiology and development. The SSLPs provide highly polymorphic anchor points that allow inheritance to be traced in any cross and provide a scaffold for assembling physical maps. Adequate physical mapping resources-notably large-insert yeast artificial chromosome (YAC) libraries-are available to support positional cloning projects based on the genetic map, but a comprehensive physical map is still a few years away. Large-scale sequencing efforts have not yet begun in mouse, but comparative sequence analysis between mouse and human is likely to provide tremendous information about gene structure and regulation.

Original languageEnglish (US)
Pages (from-to)10849-10853
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number24
DOIs
StatePublished - Nov 21 1995

ASJC Scopus subject areas

  • General

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