TY - JOUR
T1 - Mapping the brain pathways of declarative verbal memory
T2 - Evidence from white matter lesions in the living human brain
AU - Sepulcre, Jorge
AU - Masdeu, Joseph C.
AU - Sastre-Garriga, Jaume
AU - Goñi, Joaquín
AU - Vélez-de-Mendizábal, Nieves
AU - Duque, Beatriz
AU - Pastor, Maria A.
AU - Bejarano, Bartolomé
AU - Villoslada, Pablo
N1 - Funding Information:
We wish to thank Prof. Joaquin Fuster and Prof. John C. Mazziotta (University of California in Los Angeles, USA), Prof. Paul W. Glimcher (New York University, USA), Dr. John Wesseling (CIMA, University of Navarra, Spain) and Dra. Isabel Perez-Otaño (CIMA, University of Navarra, Spain) for their helpful comments, Iñigo Chalezquer for drawing Fig. 2 , Prof. Alan J. Thompson and Dra. Mara Cercignani (Institute of Neurology, London, UK) for their help in the development of the VBM protocol for MS, and the multiple sclerosis society of Navarra for their help with patient recruitment. The authors would like to acknowledge the support of the European Union (JM, 512146LSH-2003-1.2.2.-2), the Spanish Ministry of Health (JS, CM#05/00222; JM, FIS#PI052520; and PV, FIS#PI051201), the Spanish Ministry of Education and Science (MAP, SAF200-07813), the Navarra Government (JG, MAP and JM), the Basque Country Government (NVM), the foundation “UTE project CIMA” (JM and MAP) and the Fundación Uriach (PV).
PY - 2008/9
Y1 - 2008/9
N2 - Understanding the contribution of the brain white matter pathways to declarative verbal memory processes has been hindered by the lack of an adequate model in humans. An attractive and underexplored approach to study white matter region functionality in the living human brain is through the use of non-aprioristic models which specifically search disrupted white matter pathways. For this purpose, we employed voxel-based lesion-function mapping to correlate white matter lesions on the magnetic resonance images of 46 multiple sclerosis patients with their performance on declarative verbal memory storage and retrieval. White matter correlating with storage was in the temporal lobe-particularly lateral to the hippocampus and in the anterior temporal stem-, in the thalamic region and in the anterior limb of the internal capsule, all on the left hemisphere, and also in the right anterior temporal stem. The same volumes were relevant for retrieval, but to them were added temporo-parieto-frontal paramedian bundles, particularly the cingulum and the fronto-occipital fasciculus. These 3D maps indicate the white matter regions most critically involved in declarative verbal memory in humans.
AB - Understanding the contribution of the brain white matter pathways to declarative verbal memory processes has been hindered by the lack of an adequate model in humans. An attractive and underexplored approach to study white matter region functionality in the living human brain is through the use of non-aprioristic models which specifically search disrupted white matter pathways. For this purpose, we employed voxel-based lesion-function mapping to correlate white matter lesions on the magnetic resonance images of 46 multiple sclerosis patients with their performance on declarative verbal memory storage and retrieval. White matter correlating with storage was in the temporal lobe-particularly lateral to the hippocampus and in the anterior temporal stem-, in the thalamic region and in the anterior limb of the internal capsule, all on the left hemisphere, and also in the right anterior temporal stem. The same volumes were relevant for retrieval, but to them were added temporo-parieto-frontal paramedian bundles, particularly the cingulum and the fronto-occipital fasciculus. These 3D maps indicate the white matter regions most critically involved in declarative verbal memory in humans.
KW - Brain pathway
KW - Human cognition
KW - Lesion probability map
KW - Verbal declarative memory
KW - White matter
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U2 - 10.1016/j.neuroimage.2008.05.038
DO - 10.1016/j.neuroimage.2008.05.038
M3 - Article
C2 - 18585467
AN - SCOPUS:48749108980
VL - 42
SP - 1237
EP - 1243
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 3
ER -