@inproceedings{a3d27b1462db46da8cf5eb8f68c96c75,
title = "Mapping human brain function with massively parallel high-speed three-dimensional photoacoustic computed tomography",
abstract = "Photoacoustic computed tomography (PACT) has been extensively explored in animal brains but never in the human brain due to its limited field of view (FOV), imaging speed, penetration depth, and sensitivity. Here, we present the first application of PACT in functional human brain imaging. Motor and language functional tasks were employed and performed by post-hemicraniectomy patients. The brain activities were recorded at a 10-cm-diameter FOV, 350-μm/2-s spatiotemporal resolution, and ∼2-cm penetration depth using a newly developed massively parallel three-dimensional PACT system. Quantitative validation of the PACT results against 7 Tesla MRI revealed comparable angiographic structures and functional activation in the same FOV. The obtained results represent a critical step toward broader-scope human brain imaging applications using PACT technology.",
keywords = "7 Tesla MRI, functional imaging, human brain, Photoacoustic computed tomography",
author = "Shuai Na and Jonathan Russin and Li Lin and Xiaoyun Yuan and Peng Hu and Kay Jann and Lirong Yan and Konstantin Maslov and Junhui Shi and Danny Wang and Charles Liu and Lihong Wang",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Photons Plus Ultrasound: Imaging and Sensing 2021 ; Conference date: 06-03-2021 Through 11-03-2021",
year = "2021",
doi = "10.1117/12.2582652",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
address = "United States",
}