Manipulation of the microbiota for treatment of IBS and IBD - Challenges and controversies

Fergus Shanahan, Eamonn M.M. Quigley

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

There is compelling rationale for manipulating the microbiota to treat inflammatory bowel diseases (IBDs). Although studies of animal models of intestinal inflammation produced promising results, trials in humans have been disappointing. In contrast to IBD, the role of the microbiota in the development of irritable bowel syndrome (IBS) only recently has been considered, but early stage results have been encouraging. As pharmaceutical companies develop fewer truly novel agents for treatment of these disorders, consumers seek safer, long-term strategies to deal with chronic symptoms. We assess the rationale for modulating the microbiota for treatment of IBD and IBS, and discuss whether current concepts are simplistic and overstated or simply under-researched. Are claims exaggerated and expectations unrealistic? Difficulties with microbiota terminology and technologies, as well as differences among patients and the heterogeneity of these diseases, pose additional challenges in developing microbiota-based therapies for IBD and IBS.

Original languageEnglish (US)
Pages (from-to)1554-1563
Number of pages10
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - May 2014

Keywords

  • Fecal Transplantation
  • Pharmabiotic
  • Prebiotic
  • Probiotic

ASJC Scopus subject areas

  • Gastroenterology

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