Managing Manganese: The Role of Manganese Homeostasis in Streptococcal Pathogenesis

Shifu Aggarwal, Muthiah Kumaraswami

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Pathogenic streptococci require manganese for survival in the host. In response to invading pathogens, the host recruits nutritional immune effectors at infection sites to withhold manganese from the pathogens and control bacterial growth. The manganese scarcity impairs several streptococcal processes including oxidative stress defenses, de novo DNA synthesis, bacterial survival, and virulence. Emerging evidence suggests that pathogens also encounter manganese toxicity during infection and manganese excess impacts streptococcal virulence by manganese mismetallation of non-cognate molecular targets involved in bacterial antioxidant defenses and cell division. To counter host-imposed manganese stress, the streptococcal species employ a sophisticated sensory system that tightly coordinates manganese stress-specific molecular strategies to negate host induced manganese stress and proliferate in the host. Here we review the molecular details of host-streptococcal interactions in the battle for manganese during infection and the significance of streptococcal effectors involved to bacterial pathophysiology.

Original languageEnglish (US)
Article number921920
Pages (from-to)921920
JournalFrontiers in Cell and Developmental Biology
StatePublished - Jun 21 2022


  • bacterial virulence
  • manganese homeostasis
  • manganese toxicity
  • manganese uptake
  • nutritional immunity
  • streptococcal infection

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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