Management of refractory ascites in cirrhosis: Are we out of date?

Alagappan Annamalai, Lauren Wisdom, Megan Herada, Mazen Noureddin, Walid Ayoub, Vinay Sundaram, Andrew Klein, Nicholas Nissen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Cirrhosis is a major cause of morbidity and mortality worldwide with liver transplantations as it only possible cure. In the face of a significant organ shortage many patients die waiting. A major complication of cirrhosis is the development of portal hypertension and ascites. The management of ascites has barely evolved over the last hundred years and includes only a few milestones in our treatment approach, but has overall significantly improved patient morbidity and survival. Our mainstay to ascites management includes changes in diet, diuretics, shunt procedures, and large volume paracentesis. The understanding of the pathophysiology of cirrhosis and portal hypertension has significantly improved in the last couple of decades but the changes in ascites management have not seemed to mirror this newer knowledge. We herein review the history of ascites management and discuss some its current limitations.

Original languageEnglish (US)
Pages (from-to)1182-1193
Number of pages12
JournalWorld Journal of Hepatology
Issue number28
StatePublished - 2016


  • Ascites
  • Cirrhosis
  • Paracentesis
  • Portal hypertension
  • Transhepatic portosystemic shunts

ASJC Scopus subject areas

  • Hepatology


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