Management of Preinvasive Lesions

Maria G. Patrono, Camila Corzo, Maria Iniesta, Pedro T. Ramirez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Serous tubal intraepithelial carcinoma is considered the precursor lesion of high-grade serous carcinoma, and found in both low-risk and high-risk populations. Isolated serous tubal intraepithelial carcinomas in patients with BRCA1/2 mutations are detected in ∼2% of patients undergoing risk-reducing bilateral salpingo-oophorectomy and even with removal of the tubes and ovaries the rate of developing primary peritoneal carcinoma following remains up to 7.5%. Postoperative recommendations after finding incidental STICs remain unclear and surgical staging, adjuvant chemotherapy, or observation have been proposed. Discovery of STIC should prompt consideration of hereditary cancer program referral for BRCA1/2 mutation screening.

Original languageEnglish (US)
Pages (from-to)771-779
Number of pages9
JournalClinical obstetrics and gynecology
Issue number4
StatePublished - 2017


  • fallopian tube
  • ovarian cancer
  • primary peritoneal carcinoma
  • serous tubal intraepithelial carcinoma
  • survaillence

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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