Management of plastic bronchitis with nebulized tissue plasminogen activator: Another brick in the wall

Massimo Colaneri, Andrea Quarti, Marco Pozzi, Stefano Gasparini, Ines Carloni, Fernando Maria De Benedictis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated.

Original languageEnglish (US)
Article number18
JournalItalian Journal of Pediatrics
Volume40
Issue number1
DOIs
StatePublished - Feb 13 2014

Keywords

  • Plastic bronchitis
  • Primary ciliary dyskinesia
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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