Management of hepatocellular carcinoma (HCC) is a rapidly evolving field. Advances in liver surgery and transplantation mean that curative treatment can be offered to patients with HCC in compensated livers who are diagnosed early or to those who are within transplant criteria. Explanted livers have provided a growing understanding of the underlying mechanisms in hepatocarcinogenesis and diagnostic modalities. Several locoregional therapies are also available. For advanced tumors, molecular targeted therapies are yielding promising results. Because of the heterogeneity of the patients and the disease, many questions are waiting for answers through well-designed, adequately powered, and bias-free multicenter, controlled, randomized trials.

Original languageEnglish (US)
Pages (from-to)1423-1450
Number of pages28
JournalSurgical Clinics of North America
Issue number6
StatePublished - Dec 2013


  • Hepatocellular carcinoma (HCC)
  • Liver resection
  • Liver transplant
  • Locoregional therapy
  • Systemic therapy

ASJC Scopus subject areas

  • Surgery


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