Management of combined pre- and post-capillary pulmonary hypertension in advanced heart failure with reduced ejection fraction

Sandeep Sahay, Ghaleb Khirfan, Adriano R. Tonelli

Research output: Contribution to journalReview article

Abstract

Management of pulmonary hypertension (PH) has remained an unmet need in advanced left heart failure with reduced ejection fraction. In fact, patients are frequently denied heart transplant due to untreated pulmonary hypertension. The availability of mechanically circulatory devices and PH therapies has provided a ray of hope. PH specific therapies are currently not FDA approved for patients with left heart failure with reduced ejection fraction. However, clinicians have used these medications in anecdotal manner. With this review, we want to highlight the expanding use of PH specific therapy and mechanical circulatory devices in the management of PH in the setting of advanced heart failure with reduced ejection fraction.

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalRespiratory Medicine
Volume131
DOIs
StatePublished - Oct 2017

Keywords

  • Advanced heart failure
  • Left ventricular assist device
  • Mechanical circulatory devices
  • Precapillary pulmonary hypertension
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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