Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi; Lee R. Wiederhold; Gargi Roy; Rabindra Roy; Arun Jaiswal; Kishor K. Bhakat; Sankar Mitra; Tapas K. Hazra

doi:10.1016/S0300-483X(03)00289-0

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Tadahide Izumi, Lee R. Wiederhold, Gargi Roy, Rabindra Roy, Arun Jaiswal, Kishor K. Bhakat, Sankar Mitra, Tapas K. Hazra

Academic Institute

Research output: Contribution to journal › Review article

167 Scopus citations

Abstract

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.

Original language	English (US)
Pages (from-to)	43-65
Number of pages	23
Journal	Toxicology
Volume	193
Issue number	1-2
DOIs	https://doi.org/10.1016/S0300-483X(03)00289-0
State	Published - Nov 15 2003

Keywords

Base excision repair
DNA
Reactive oxygen species

ASJC Scopus subject areas

Toxicology

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10.1016/S0300-483X(03)00289-0

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AU - Izumi, Tadahide

AU - Wiederhold, Lee R.

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AU - Roy, Rabindra

AU - Jaiswal, Arun

AU - Bhakat, Kishor K.

AU - Mitra, Sankar

AU - Hazra, Tapas K.

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KW - DNA

KW - Reactive oxygen species

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