Malignant melanoma arising in an ovarian carcinosarcoma: Case report and review of the literature

Andres A. Roma, Anais Malpica, Michael T. Deavers

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume30
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Carcinosarcoma
  • HMB-45
  • Melanoma
  • Melanotic neuroectodermal tumor of infancy
  • Ovary-Malignant mixed mullerian tumor
  • S-100

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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