Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy

Mary L. Ostrowski, Mark E. Johnson, Luan Truong, M. John Hicks, Frank E. Smith, Harlan J. Spjut

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We report a rare case of malignant chondroblastoma, which presented in a 47-year-old man as a recurrent tumor, 18 years following wide excision of a typical pelvic chondroblastoma. Radiologic studies of the recurrent tumor showed a large, lytic, destructive lesion of the right pelvic bones and femur, with a pathologic fracture of the latter, a large pelvic soft tissue mass, and multiple pulmonary metastases. Biopsy tissue showed typical features of chondroblastoma, but also increased nuclear atypia, hyperchromasia, and pleomorphism, compared to the original tumor, and, most significantly, abnormal mitotic figures. Immunohistochemical studies of the recurrent tumor revealed p53 mutation and extensive proliferative activity, and flow cytometric studies showed DNA aneuploidy, none of which was present in the original tumor. The patient received chemotherapy and radiation, but died of disease eight months after presentation. We also review chondroblastoma in general, to assign this unusual lesion to a tumor subtype.

Original languageEnglish (US)
Pages (from-to)644-650
Number of pages7
JournalSkeletal Radiology
Volume28
Issue number11
DOIs
StatePublished - Nov 1 1999

Keywords

  • Aneuploidy
  • Chondroblastoma, malignant, recurrent
  • CT
  • Femur
  • p53 mutation
  • Pelvis
  • Xray

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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