Male adnexal tumour of probable Wolffian origin occurring in a seminal vesicle

L. P. Middleton, M. J. Merino, S. M. Popok, N. G. Ordonez, A. G. Ayala, J. Y. Ro

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Aims: Adnexal tumours of probable Wolffian origin are rare low-grade malignant neoplasms that have been previously described in the broad ligament, ovaries and retroperitoneum of females. All are characterized by small, bland epithelial cells growing in a diffuse, trabecular, or tubular pattern. The majority of the cases reported have pursued a benign clinical course. However, recurrences and distant metastases have been described. We present a case of a male adnexal tumour of probable Wolffian origin occurring in the left seminal vesicle of a 29-year-old man with 23 years of follow-up. Results: The diagnosis is supported by immunohistochemical and electron microscopic findings: The tumour cells were immunoreactive for cytokeratin and vimentin while smooth muscle antigen and S100 protein were uniformly negative. By electron microscopy cells were arranged in an acinar pattern and surrounded flocculent, electron-dense material. Individual cells contained numerous dense bodies and free ribosomes. The patient had recurrences at 14 and 23 years after initial diagnosis. Conclusion: This is the first report of this entity in a male. The literature on this unusual tumour is reviewed and the clinicopathological, immunohistochemical and ultrastructural features are described. The differential diagnosis of this seemingly indolent tumour is discussed with genitourinary tumours having a more aggressive clinical course.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
Issue number3
StatePublished - 1998


  • Female adnexal tumour
  • Seminal vesicle
  • Wolffian

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology


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