Malakoplakia of the vagina diagnosed by fine‐needle aspiration cytology

A. Joe Saad, Teresa M. Donovan, Luan Truong

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Malakoplakia is an uncommon chronic granulomatous process that most commonly affects the urinary tract, but it may rarely recur in the female genital tract. It appears to result from a defect in macrophage function resulting in an inability to destroy ingested bacteria. We describe the fine needle aspiration cytology of malakoplakia in an 84‐yr‐old woman presenting with a large pelvic mass involving the apex of the vagina. The patient's history was significant for cervical squamous cell carcinoma in the remote past. CT‐guided needle aspiration yielded cellular smears with large numbers of isolated histiocytes, as well as polymorphonuclear leukocytes, lymphocytes, and plasma cells. The histiocytes had central nuclei and abundant granular cytoplasm containing target‐shaped, laminated bodies (Michaelis‐Gutmann bodies). These bodies were PAS positive and focally von Kossa positive. Large numbers of intracellular and extracellular bacteria were also seen on the smears. The characteristic cytologic findings obtained by needle aspiration were diagnostic of malakoplakia with a rare and unusual clinical presentation.

Original languageEnglish (US)
Pages (from-to)559-561
Number of pages3
JournalDiagnostic Cytopathology
Volume9
Issue number5
DOIs
StatePublished - Jan 1 1993

Keywords

  • Electron microscopy
  • Fine‐needle aspiration
  • Malakoplakia
  • Michaelis‐Gutmann body
  • Vagina

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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