Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo

D. Sostman, S. Rockwell, G. J.W. Smith, J. C. Gore, K. A. Kennedy, A. Habib, J. J. Fischer, I. M. Armitage, W. Holcomb

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We studied histology, findings on H-1 magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microelectrode pH and pO2 measurements in the BA1112 rhabdomyosarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO2 values and P-31 MR evidence for impaired metabolic status.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalInvestigative Radiology
Issue number4
StatePublished - Apr 1988


  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Neoplasm histology
  • Neoplasm physiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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