Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain

Alessio Adamiano, Victoria M. Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.

Original languageEnglish (US)
Pages (from-to)1267-1289
Number of pages23
JournalNanomedicine
Volume14
Issue number10
DOIs
StatePublished - 2019

Keywords

  • calcium phosphate
  • composite nanoparticles
  • glioblastoma
  • magnetic hyperthermia
  • nanoparticles
  • osteosarcoma

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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