Magnetic bioactive and biodegradable hollow fe-doped hydroxyapatite coated poly(l -lactic) acid micro-nanospheres

Michele Iafisco, Monica Sandri, Silvia Panseri, José Manuel Delgado-López, Jaime Gómez-Morales, Anna Tampieri

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Superparamagnetic iron-substituted hydroxyapatite nanocrystals (FeHA) were used as a particulate emulsifier for the preparation of hybrid polymeric-inorganic materials by Pickering emulsion. As result, magnetic hollow micro-nanospheres (ranging from 2 μm to 500 nm) made of a polymeric shell of poly(l-lactic) acid coated with FeHA have been prepared. Several hybrid composites containing different amounts of inorganic phase loaded to the polymeric shell were prepared. The amount of FeHA strongly affected the chemical-physical features of the spheres such as size, polymer crystallinity, surface charge, and magnetization. They displayed good biocompatibility toward bone marrow mesenchymal stem cells, and the spheres coated with higher amount of FeHA exhibited better cell proliferation than those coated with lower amount. These magnetic materials have potential uses as building blocks for the preparation of scaffolds for hard tissue regeneration as well as carriers of biomolecules for nanomedical applications.

Original languageEnglish (US)
Pages (from-to)2610-2617
Number of pages8
JournalChemistry of Materials
Volume25
Issue number13
DOIs
StatePublished - Jul 9 2013

Keywords

  • biomaterials
  • hydroxyapatite
  • magnetism
  • microspheres
  • nanoparticles
  • poly(l -lactic) acid

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemical Engineering(all)
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Magnetic bioactive and biodegradable hollow fe-doped hydroxyapatite coated poly(l -lactic) acid micro-nanospheres'. Together they form a unique fingerprint.

Cite this