Magnetic and morphological properties of ferrofluid-impregnated hydroxyapatite/ collagen scaffolds

Alberto Riminucci, Chiara Dionigi, Chiara Pernechele, Giulia de Pasquale, Tilde de Caro, Gabriel Maria Ingo, Francesco Mezzadri, Nathalie Bock, Massimo Solzi, Giuseppina Padeletti, Monica Sandri, Anna Tampieri, V. Alek Dediu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this article we present the morphological and magnetic characterization of ferrofluid-impregnated biomimetic scaffolds made of hydroxyapatite and collagen used for bone reconstruction. We describe an innovative and simple impregnation process by which the ferrofluid is firmly adsorbed onto the hydroxyapatite/collagen scaffolds. The process confers sufficient magnetization to attract potential magnetic carriers, which may be used to transport bioactive agents that favour bone regeneration. The crystalline structure of the magnetite contained in the ferrofluid is preserved and its quantity, estimated from the weight gain due to the impregnation process, is consistent with that obtained from energy dispersive X-ray spectroscopy. The magnetization, measured with a superconducting quantum interference device, is uniform throughout the scaffolds, demonstrating the efficiency of the impregnation process. The field emission gun scanning electron microscopy characterization demonstrates that the process does not alter the morphology of the hydroxyapatite/collagen scaffolds, which is essential for the preservation of their bioactivity and consequently for their effectiveness in promoting bone formation.

Original languageEnglish (US)
Pages (from-to)2679-2687
Number of pages9
JournalScience of Advanced Materials
Volume6
Issue number12
DOIs
StatePublished - 2014

Keywords

  • Bone regeneration
  • Collagen
  • Hydroxyapatite
  • Magnetic nanoparticles
  • Magnetic scaffolds

ASJC Scopus subject areas

  • Materials Science(all)

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