Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

Keyphrases

• Macrophages 100%
• Gemcitabine 100%
• Pancreatic Adenocarcinoma 100%
• Cytidine Deaminase 100%
• Gemcitabine Resistance 100%
• Pancreatic Ductal Adenocarcinoma 87%
• Tumor-associated Macrophages 75%
• Chemotherapy 37%
• Cancer Cells 25%
• Tumor 12%
• Nucleoside Analogues 12%
• Metabolism 12%
• Cell-Associated 12%
• Apoptosis 12%
• Induced Apoptosis 12%
• Transgenic Mice 12%
• Microenvironment 12%
• Cancer Tumor 12%
• Protective Effect 12%
• Survival Rate 12%
• Macrophage Recruitment 12%
• Receptor Antagonist 12%
• Pancreatic Duct Cells 12%
• Monocyte-derived Macrophages 12%
• Cancer Progression 12%
• Cell-blocking 12%
• Multiple Proteins 12%
• Poor Survival 12%
• Pro-tumorigenic 12%
• Tumor Factor 12%
• Pharmacologic Agents 12%
• Macrophage Activation 12%
• Acquired Resistance 12%
• Paracrine Effect 12%
• GM-CSF Receptor 12%
• Human Carcinoma 12%
• Chemoresistance 12%
• Caspase-3 Pathway 12%
• Cancer Dissemination 12%
• GW2580 12%
• Macrophage Conditioned Medium 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Gemcitabine 100%
• Pancreas Adenocarcinoma 100%
• Cytidine Deaminase 100%
• Neoplasm 66%
• Chemotherapy 33%
• Malignant Neoplasm 22%
• Nucleoside Analog 11%
• Cancer Growth 11%
• Carcinoma 11%
• Survival Rate 11%
• Caspase 3 11%
• Transgenic Mouse 11%
• Receptor Antagonist 11%
• Drug Resistance 11%

Biochemistry, Genetics and Molecular Biology

• Gemcitabine 100%
• Macrophage 100%
• Cytidine Deaminase 100%
• Tumor-Associated Macrophage 66%
• Programmed Cell Death 22%
• Cancer Cell 22%
• Enzyme 11%
• Metabolic Pathway 11%
• Caspase 3 11%
• Upregulation 11%
• Survival Rate 11%
• Transgenic Mouse 11%
• Receptor Antagonist 11%
• Nucleoside Analog 11%
• Drug Resistance 11%