Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase

Moran Amit; Ziv Gil

doi:10.4161/onci.27231

Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase

Moran Amit, Ziv Gil

Academic Institute

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.

Original language	English (US)
Article number	e27231
Journal	OncoImmunology
Volume	2
Issue number	12
DOIs	https://doi.org/10.4161/onci.27231
State	Published - 2013

Keywords

Chemotherapy
Cytidine deaminase
Gemcitabine
Macrophages
Pancreatic ductal adenocarcinoma
Resistance

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/onci.27231

Cite this

@article{054413c382254f3893935dacc59e5f02,

title = "Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase",

abstract = "Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.",

keywords = "Chemotherapy, Cytidine deaminase, Gemcitabine, Macrophages, Pancreatic ductal adenocarcinoma, Resistance",

author = "Moran Amit and Ziv Gil",

year = "2013",

doi = "10.4161/onci.27231",

language = "English (US)",

volume = "2",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Taylor and Francis Ltd.",

number = "12",

}

TY - JOUR

T1 - Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase

AU - Amit, Moran

AU - Gil, Ziv

PY - 2013

Y1 - 2013

N2 - Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.

AB - Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.

KW - Chemotherapy

KW - Cytidine deaminase

KW - Gemcitabine

KW - Macrophages

KW - Pancreatic ductal adenocarcinoma

KW - Resistance

UR - https://www.scopus.com/pages/publications/84894578451

UR - https://www.scopus.com/inward/citedby.url?scp=84894578451&partnerID=8YFLogxK

U2 - 10.4161/onci.27231

DO - 10.4161/onci.27231

M3 - Article

AN - SCOPUS:84894578451

SN - 2162-4011

VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 12

M1 - e27231

ER -

Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this