Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase

Moran Amit, Ziv Gil

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.

Original languageEnglish (US)
Article numbere27231
JournalOncoImmunology
Volume2
Issue number12
DOIs
StatePublished - 2013

Keywords

  • Chemotherapy
  • Cytidine deaminase
  • Gemcitabine
  • Macrophages
  • Pancreatic ductal adenocarcinoma
  • Resistance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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