Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

Jarek Wosik, Martha Suarez-Villagran, John H. Miller, R. Mark Ghobrial, Malgorzata Kloc

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalImmunologic Research
Volume67
Issue number1
DOIs
StatePublished - Feb 2019

Keywords

  • Actin
  • Cancer
  • Macrophage
  • Magnetic field
  • RhoA
  • Transplantation

ASJC Scopus subject areas

  • Immunology

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