Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.

Original languageEnglish (US)
Pages (from-to)99-109
Number of pages11
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number1
Early online dateJan 2019
StateE-pub ahead of print - Jan 2019


  • CX3CR1
  • ROCK kinase
  • RhoAactin
  • macrophages
  • wound healing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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