@inbook{3701939fc61b4784a2e6ce9b17808506,
title = "Macrophage Actin Cytoskeleton in Chronic Rejection",
abstract = "There is no cure for chronic rejection of transplanted organs. Macrophages are heavily involved in chronic rejection. Macrophages{\textquoteright} movement into the graft depends on the actin cytoskeleton and its regulators the GTPase RhoA and its effector ROCK kinase. In this chapter, we describe how the interference with macrophage RhoA/ROCK pathway disrupts macrophage actin cytoskeleton, impairing their functions and migration to the allograft, and preventing the development of chronic rejection, and how such interference can be applied to clinical therapies.",
keywords = "Actin, Allograft, Chronic rejection, Macrophage, Mechanotransduction, RhoA, ROCK",
author = "Malgorzata Kloc and Marta Halasa and Thabet, \{Souhail A.\} and Jarek Wosik and Ahmed Uosef and Arijita Subuddhi and Ghobrial, \{Rafik Mark\}",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.",
year = "2026",
doi = "10.1007/978-3-032-07686-1\_6",
language = "English (US)",
series = "Results and Problems in Cell Differentiation",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "135--150",
booktitle = "Results and Problems in Cell Differentiation",
address = "Germany",
}